Journal article
Impact of intermittent preventive treatment in pregnancy with azithromycin-containing regimens on maternal nasopharyngeal carriage and antibiotic sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus: A cross-sectional survey at delivery
HW Unger, C Aho, M Ome-Kaius, RA Wangnapi, AJ Umbers, W Jack, A Lafana, A Michael, S Hanieh, P Siba, I Mueller, AR Greenhill, SJ Rogerson
Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2015
DOI: 10.1128/JCM.03570-14
Abstract
Sulfadoxine-pyrimethamine (SP) plus azithromycin (AZ) (SPAZ) has the potential for intermittent preventive treatment of malaria in pregnancy (IPTp), but its use could increase circulation of antibiotic-resistant bacteria associated with severe pediatric infections. We evaluated the effect of monthly SPAZ-IPTp compared to a single course of SP plus chloroquine (SPCQ) on maternal nasopharyngeal carriage and antibiotic susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus at delivery among 854 women participating in a randomized controlled trial in Papua New Guinea. Serotyping was performed, and antibiotic susceptibility was evaluated by disk diffusion an..
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Funding Acknowledgements
This work was supported by the Malaria in Pregnancy Consortium, through a grant from the Bill and Melinda Gates Foundation (grant number 46099); the Pregvax Consortium, through a grant from the European Union's Seventh Framework Programme FP7-2007-HEALTH (grant number PREGVAX 201588); the Spanish Government (EUROSALUD 2008 Programme); and Pfizer Inc. (investigator-initiated research grant WS394663).